ADVANCING THE PHARMACOLOGICAL TREATMENT OF TOBACCO AND NICOTINE DEPENDENCE

An independently-reviewed competitive grants program supported by Pfizer

Previous GRAND Awards

Previously, Global Research Awards for Nicotine Dependence (GRAND) were awarded to the following projects, which are listed by year and in alphabetical order by applicant surname.

2017
Name Award (US$) Affiliation Proposal Title
Eugeni Bruguera 107,518 Psychiatry Department, Vall d’Hebron Hospital/Research Institute, Barcelona, Spain An effectiveness and safety study of varenicline for smoking cessation in hospitalized patients with psychiatric disorders
Johnson George 199,900 Monash University, Victoria, Australia Varenicline And NIcotine replacement therapy for Smokers admitted to Hospitals (VANISH)
Yanhui Liao 100,000 Mental Health Institute, The Second Xiangya Hospital, Central South University, Hunan province, P.R.China Boosting Chinese healthcare service providers’ utilization of behavioral and pharmacotherapy interventions for cigarette smoking cessation by 'WeChat WeQuit' program
Stjepan Oreskovic 199,860 University of Zagreb, Croatia Varenicline versus Cytisine for Smoking Cessation in the Primary Care Setting in Croatia and Slovenia - A Pilot Randomized Controlled Trial
Lion Shahab 199,799 University College London, UK E-cigarettes to Augment Stop Smoking In-person Support and Treatment with varenicline (E-ASSIST) - a randomised controlled trial
Witold Zatoński 199,800 Health Promotion Foundation, Poland The effect of cytisine and a multimodal digitally facilitated behavioural intervention delivered in secondary care for cancer patients: a randomized factorial trial
2016
Ismail Celik 75,388 Hacettepe University Cancer Institute, Sihhiye, Ankara, Turkey 5-Year outcomes of varenicline in a nation-wide population-based smoking cessation support program
Paraskevi Katsaounou 181,855 Pulmonary and Critical Care Department, Evangelismos Hospital, Athens, Greece Medical group support through Social media for Smoking cessation in diabetic patients
Bernard Le Foll 185,000 Centre for Addiction and Mental Health, Toronto, ON, Canada Deep rTMS and varenicline for smoking cessation: A pilot study exploring the efficacy of a combined treatment approach
Peter Selby 184,762 Centre for Addiction and Mental Health, Toronto, ON, Canada Tobacco addiction treatment implementation and scale up in dental care settings: A mixed methods study
Pramil Singh 185,000 Center for Health Research, School of Public Health, Loma Linda University, Loma Linda, CA, USA Comparative effectiveness of cytisine versus nicotine replacement therapy (NRT) in the National Smoking Cessation Program of Mongolia: A pragmatic non-inferiority trial
Tuula Toljamo 184,956 Lapland Central Hospital, Rovaniemi, Finland Efficacy and safety of e-cigarettes for smoking cessation in middle-aged heavy smokers
2015
Abraham Bohadana 107,963 Pulmonary Institute, Shaare Zedek Medical Center, Jerusalem, Israel Varenicline for “gradual” vs. “abrupt” smoking cessation in low-motivated COPD smokers: A randomized pilot study
Pasquale Caponnetto 171,488 University of Catania, Italy Efficacy of smoking cessation with varenicline for e-cigarettes users: A randomized controlled trial
Andrea King 191,546 The University of Chicago, IL, USA Evaluation of varenicline augmentation of patch outcomes in heavy drinkers’ smoking cessation
Philip Smith 147,943 Department of Psychiatry, Yale University School of Medicine, CT, USA Improving precision medicine for smoking cessation: Examining variability in clinical trial treatment response
Rachel Tyndale 189,492 Department of Pharmacology, University of Toronto, ON, Canada Sources of variation in varenicline levels: Impact on abstinence in four clinical trials of African-American and White smokers
Laurie Anne Zawertailo 191,566 Centre for Addiction and Mental Health, University of Toronto, ON, Canada Using non-invasive brain stimulation (tDCS) to improve the effectiveness of varenicline for treating tobacco dependence: A randomized controlled trial
2014
Hassan Chami 190,320 American University of Beirut Medical Center, Lebanon Evaluation of varenicline for Waterpipe smoking cessation
Danja Przulj 169,886 Queen Mary, University of London, UK Increasing the dose of nicotine replacement treatment to individual needs: A pilot study
Lion Shahab 179,225 University College London, UK Short- and long-term smoking cessation treatment outcomes: impact of nicotine metabolite ratio on pharmacotherapy effectiveness
Kamran Siddiqi 199,980 University of York, UK The efficacy of varenicline in achieving abstinence among hookah smokers: A two-arm, double-blind, randomised, placebo-controlled trial
Amy Taylor 139,076 University of Bristol, UK Investigating the effectiveness of varenicline for long-term smoking cessation and its impact on longer-term health outcomes in a real-world setting
Harriet de Wit 121,056 The University of Chicago, IL, USA Oxytocin as a potential adjunct in treatment for smoking cessation
2013
Lauren A. Beupre 198,664 Departments of Physical Therapy and Surgery (Orthopaedic Surgery), University of Alberta, Edmonton, AB, Canada Evaluating smoking cessation as a preoperative standard of care for total hip or knee arthroplasty in a centralized intake clinic model
Abraham B. Bohadana 126,210 Pulmonary Institute, Shaare Zedek Medical Center, Jerusalem, Israel Evaluation of extended (6-week) varenicline preloading: Does it facilitate smoking reduction and cessation?
Stuart Ferguson 186,106 Schools of Medicine & Pharmacy, University of Tasmania, Hobart, Tasmania, Australia Examination of the mechanism of action of two pre-quit pharmacotherapies for smoking cessation
Ilan Goldenberg 199,150 Leviev Heart Center , Sheba Medical Center, Tel Hashomer, Israel Early in-hospital initiation of pharmacotherapy for smoking cessation, concomitant with nurse-led support, in patients after acute coronary syndrome (ACS)
Tobias Raupach 163,195 University Medical Centre Göttingen, Dept. of Cardiology and Pneumology, Göttingen, Germany Increasing medication adherence in smoking cessation: A randomised-controlled trial of a smartphone application
Theresa Winhusen 144,423 University of Cincinnati College of Medicine, Cincinnati, OH, USA A pilot randomized, placebo-controlled, crossover study of the effect of the nicotine nasal spray and varenicline on cigarette smoking following methadone dosing in methadone-maintained patients
2012
Jonathan Foulds 200,000 Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA Pilot randomized trial of an automated smoking cessation intervention via mobile phone text messages as an adjunct to varenicline in primary care
Michael Kotlyar 200,000 University of Minnesota, Minneapolis, Minnesota, USA Use of medicinal nicotine for preventing cue induced craving and withdrawal symptoms
Robert Reid 199,838 University of Ottawa Heart Institute, Ottawa, Ontario, Canada A prospective cluster-randomized trial to implement the Ottawa Model for Smoking Cessation in diabetes education programs in Canada
Victoria Wing 199,929 Centre for Addiction and Mental Health, Toronto, Ontario, Canada Evaluating the effects of varenicline on smoking lapse in smokers with and without schizophrenia: Implications for treatment
Laurie Zawertailo 199,800 Centre for Addiction and Mental Health, Toronto, Ontario, Canada Evaluating the real-world effectiveness of varenicline and bupropion for long-term smoking cessation
2011
Jasjit S. Ahluwalia 200,000 University of Minnesota Medical School, Minneapolis, USA Factors influencing nondaily cigarette smoking and cessation
Anneke Bühler

191,620

IFT Institut für Therapieforschung, München, Germany Maturing out: The role of internal and external control mechanisms in daily situations of subtypes of smokers and their implications for treatment
Maciej Goniewicz 185,882 Bart’s and the London School of Medicine and Dentistry, Wolfson Institute of Preventive Medicine, Queen Mary University of London, UK Comparison of the effects of the electronic cigarette and nicotine inhalator on tobacco withdrawal symptoms over 24 hours of abstinence
Suchitra Krishnan-Sarin 199,995 Yale University, School of Medicine, New Haven, Connecticut, USA  Examining the effects of varenicline on reward responses, cognition, and tobacco cues in adolescent smokers
Bernard Le Foll, MD 200,000 Centre for Addiction and Mental Health, Toronto, Canada Testing the PPAR hypothesis of nicotine dependence in humans
Francesco Versace 200,000 The University of Texas MD Anderson Cancer Center, Houston, Texas, USA Cortical reactivity to pleasant and cigarette cues: A conditioning paradigm
2010
Angela Attwood 64,646 University of Bristol, Bristol, UK A placebo-controlled study of the effectiveness of D-cycloserine in reducing cue reactivity during cue-exposure therapy in daily cigarette smokers
Fiammetta Cosci 59,687 Department of Psychology, University of Florence, Florence, Italy  The effects of nicotine withdrawal on panic-like response to breath holding: A placebo-controlled, double-blind, cross-over patch study
Bernard Le Foll 200,000 Centre for Addiction and Mental Health, Toronto, Ontario, Canada  Does the insula control smoking-induced dopamine release? A TMS/11C-PHNO study in humans 
Keir Lewis 115,401 School of Medicine, Swansea University, Swansea, Wales, UK  Does smoking status after a diagnosis of lung cancer affect outcomes?
Hayden McRobbie 190,401 Wolfson Institute of Preventative Medicine, Barts and The London School of Medicine and Dentistry, London, UK  Complementing current pharmacological treatments for smokers with 'sensory replacement': The role of low nicotine cigarettes
Lara A. Ray 160,654 University of California, Los Angeles, California, USA The effects of varenicline on stress-induced and cue-induced cigarette craving: A placebo-controlled laboratory study
Riju Ray 199,999 University of Pennsylvania, Philadelphia, USA Nicotinic receptor availability in slow and fast nicotine metabolizers
Marc L. Steinberg 200,000 Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA Investigation of varenicline-aided cigarette reduction in smokers not ready to quit
2009
Chris Bolliger 150,00 Faculty of Health Sciences Respiratory Research Unit, Quit Support, South Africa Evaluation of varenicline in combination with nicotine replacement therapy for smoking cessation
Margaret Clark 100,000 The Ohio State University College of Nursing, Columbus, Ohio, USA Web-based smoking cessation for women: A pilot study
Joseph R. DiFranza 120,000 University of Massachusetts Medical School, Massachusetts, USA BDNF – A potential biomarker of nicotine withdrawal
Anne Jackson 150,000 University of Brighton, Brighton, UK Study of the effect of varenicline on inhibitory control in smokers
Bernard Le Foll 150,000 University of Toronto, Ontario, Canada A C11 PHNO PET study in smokers to measure the dopamine-releasing effects of presentation of tobacco-associated stimuli
Riccardo Polosa 150,000 University of Catania, Catania, Italy Efficacy of smoking cessation with varenicline in diabetic smokers: A randomized controlled trial
William Wadland 75,000 Michigan State University, East Lansing, Michigan, USA Preventing relapse to smoking in post partum women
2008
Li-Shiun Chen 50,000 Washington University, St Louis, Missouri, USA Nicotine dependence: Synthesizing genetic and environmental risks
Eric Donny 150,000 University of Pittsburgh, Pennsylvania, USA   Neurobiological correlates of reward dysfunction in daily smokers varying in nicotine dependence
Karen Hartwell 50,000 Medical University of South Carolina, South Carolina, USA Investigation of the varenicline on BOLD fMRI activation during smoking cue-induced craving in nicotine-dependent individuals
Jean-Charles Hoda 50,000 University of Geneva, Geneva, Switzerland Functional properties of a genetic risk variant in the α5 subunit of nicotinic acetylcholine receptors associated with nicotine dependence and lung cancer
Jaakko Kaprio 150,000 University of Helsinki, Helsinki, Finland Finnish genetic epidemiologic study on nicotine dependence and smoking cessation
Milan Khara 150,000 University of British Columbia, British Columbia, Canada An examination of the efficacy, safety, and sex and gender differences in using varenicline as an aid to smoking cessation in a population of methadone maintained opioid dependent patients: A pilot trial
Amy Lazev 50,000 Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA A new treatment for smokers with high negative affect
Bernard Le Foll 50,000 Centre for Addiction and Mental Health, Toronto, Ontario, Canada Role of insula in nicotine-seeking behavior in rats
James MacKillop 50,000 Brown University, Providence, Rhode Island, USA Understanding craving for cigarettes via behavioral economics
Martin Mahoney 150,000 Rosswell Park Cancer Institute, Buffalo, New York, USA Extended pre-cessation varenicline for smoking cessation: A pilot study
Marc Mooney 150,000 University of Minnesota, Minneapolis, USA Human laboratory evaluation of combination pharmacotherapy for nicotine dependence: Varenicline and bupropion
Andrew Strasser 150,000 University of Pennsylvania, Philadelphia, Pennsylvania, USA Extinction of smoking topography and behaviors during response to varenicline

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